Utility of ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in Evaluating Disseminated Nontuberculous Mycobacterial Infection in Patients With Anti-interferon-γ Autoantibodies.

ABSTRACT:

Background

Managing disseminated nontuberculous mycobacterial (NTM) infection in patients with neutralizing anti-interferon-γ autoantibodies (AIGAs) poses substantial challenges due to the lack of established treatment guidance and predictive tools for clinical outcomes. In this study, we investigated the utility of ¹⁸F-fluorodeoxyglucose (2-[¹⁸F]FDG) positron emission tomography (PET) in guiding treatment decisions, with a focus on its ability to predict rehospitalization outcomes.

Methods

We conducted a post hoc analysis of the first available 2-[¹⁸F]FDG PET scans of patients with AIGAs and disseminated NTM infection from a prospective observational multicenter cohort. Cox proportional hazards regression was used to determine predictors for

SUBMITTER: Chuang PJ 

PROVIDER: S-EPMC11656338 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature