Incidence of antibody-drug conjugate-related hepatotoxicity in breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Antibody-drug conjugates (ADCs), as a new type of targeted drug, have been widely used in breast cancer patients in recent years. However, while achieving better efficacy, its hepatotoxicity should not be ignored.

Objectives

To clarify the incidence of hepatotoxicity associated with ADCs and compare the incidence of hepatotoxicity of ADCs with different drugs.

Design

We performed a systematic review and meta-analysis to summarize the clinical trials and combined the data using meta-analysis.

Methods

We searched the PubMed, Embase, and Web of Science databases up to March 12, 2023. The primary outcome was the incidence of ADC-related hepatotoxicity in breast cancer patients. The data were merged using Stata 17.0 software.

Results

ADCs caused a

SUBMITTER: Yang P 

PROVIDER: S-EPMC11656431 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature