DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity.

ABSTRACT: SUMOylation, the modification of proteins with a small ubiquitin-like modifier (SUMO), is known to regulate various cellular events, including cell division. This process is dynamic, with its status depending on the balance between SUMOylation and deSUMOylation. While the regulation of cell division by sentrin-specific protease (SENP) family proteins through deSUMOylation has been investigated, the role of another deSUMOylase, deSUMOylating isopeptidase 1 (DESI1), remains unknown. In this study, we explored DESI1's role in cell division. Knockdown of DESI1 accelerated cell division progression, leading to a significant increase in abnormal chromosome segregation. These phenotypes were rescued by re-expression of wild-type DESI1, but not catalytically inactive DESI1. DESI1 knockdown reduced

SUBMITTER: Ikeda Y 

PROVIDER: S-EPMC11656513 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature