On the surface: Skin microbial exposure contributes to allergic disease.

ABSTRACT:

Objective

To discuss the skin microbiome modulates immunity by interactions between skin immunology with keratinocytes to combat pathogens. Allergic disorders are classified by immunoglobulin E sensitivity and aberrant T_H2 cell responses, and an increasing number of studies have described the associations with skin microbiome fluctuations. In this review, we discuss commensal-epidermal homeostasis and its influence on allergic disease.

Data sources

All included references were obtained from the PubMed database.

Study selections

Studies addressing relevant aspects of commensal-epidermal homeostasis, skin microbiome dysbiosis, microbiome-targeted therapeutics, and prevention in allergy were included.

Results

Homeostasis between the commensal microbiome

SUBMITTER: DeVore SB 

PROVIDER: S-EPMC11656525 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature