Genetic overlap between breast cancer and sarcopenia: exploring the prognostic implications of SLC38A1 gene expression.

ABSTRACT:

Background

Sarcopenia, an age-related syndrome characterized by a decline in muscle mass, not only affects patients' quality of life but may also increase the risk of breast cancer recurrence and reduce survival rates. Therefore, investigating the genetic mechanisms shared between breast cancer and sarcopenia is significant for the prevention, diagnosis, and treatment of breast cancer.

Methods

This study downloaded gene expression datasets and clinical data related to breast cancer and skeletal muscle aging from the GEO database. Data preprocessing, integration, differential gene identification, functional enrichment analysis, and construction of protein-protein interaction networks were performed using R language. Subsequently, COX proportional hazards model analysis and su

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11656554 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature