Adipocyte-derived CXCL10 in obesity promotes the migration and invasion of ovarian cancer cells.

ABSTRACT:

Background

As a widespread epidemic, obesity poses a significant risk to health and leads to physiological abnormalities, including diabetes mellitus and inflammation. Obesity-induced inflammation can accelerate the development of various cancers; however, the role of obesity in the migration of ovarian carcinoma is still unclear.

Results

Twenty-four commonly upregulated genes were identified from single-cell RNA sequencing datasets of both ovarian carcinoma and adipose tissue of obese humans, with the chemokine CXCL10 showing a significant increase in adipose tissues associated with obesity. And CXCL10 treated primed macrophages exhibit both direct and indirect effects on the proliferation, apoptosis, migration, and invasion of ovarian adenocarcinoma cells. The treatment of

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11656578 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature