Spatiotemporally Guided Single-Atom Bionanozyme for Targeted Antibiofilm Treatment.

ABSTRACT: The heterogeneous and dynamic microenvironment of biofilms complicates bacterial infection treatment. Nanozyme catalytic therapy has recently been promising in treating biofilm infections. However, active nanozymes designed with the required precision targeting the biofilm microenvironment are lacking. This work proposes a spatiotemporally guided single-atom bionanozyme (BioSAzyme) for targeted antibiofilm therapy based on protein engineering of copper single-atom nanozyme (Cu SAzyme). The Cu SAzyme, synthesized via a novel mechanochemistry-assisted method, features highly accessible Cu-N₄ active sites exposed on 2D N-doped carbon, exhibiting excellent triple enzyme-like activities according to experimental results and density functional theory calculations. Inheriting biofuncti

SUBMITTER: Huang L 

PROVIDER: S-EPMC11656685 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature