PHP-Family Diesterase from <i>Novosphingobium</i> with Broad Specificity and High Catalytic Efficiency against Organophosphate Flame-Retardant Derived Diesters.

ABSTRACT: Organophosphate flame retardants have been widely used in plastic products since the early 2000s. Unfortunately, these compounds leach out of the plastics over time and are carcinogenic, developmental toxins, and endocrine disruptors. Due to the high usage levels and stable nature of the compounds, widespread contamination of the environment has now been observed. Despite their recent introduction into the environment, bacteria from the Sphingomonadaceae family have evolved a three-step hydrolytic pathway to utilize these compounds. The second step in this pathway in Sphingobium sp. TCM1 is catalyzed by Sb-PDE, which is a member of the polymerase and histidinol phosphatase (PHP) family of phosphatases. This enzyme is only the second case of a PHP-family enzyme capable

SUBMITTER: Garner P 

PROVIDER: S-EPMC11656708 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature