Neutrophil prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal <i>Salmonella enterica</i> serovars.

ABSTRACT: Nontyphoidal strains of Salmonella enterica are a major cause of foodborne illnesses, and infection with these bacteria results in inflammatory gastroenteritis. Polymorphonuclear leukocytes (PMNs), also known as neutrophils, are a dominant immune cell type found at the site of infection in Salmonella-infected individuals, but how they regulate infection outcome is not well understood. Here, we used a co-culture model of primary human PMNs and human intestinal organoids to probe the role of PMNs during infection with two of the most prevalent Salmonella serovars: Salmonella enterica serovar Enteritidis and Typhimurium. Using a transcriptomics approach, we identified a dominant role for PMNs in mounting differential immune responses including production of pro-inf

SUBMITTER: Lawrence A-LE 

PROVIDER: S-EPMC11656734 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature