Maternal group B Streptococcus decreases infant length and alters the early-life microbiome: a prospective cohort study.

ABSTRACT:

Background

Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota's importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics.

Methods

We recruited and classified 453 pregnant women from southern China into GBS or healthy groups based on GBS vaginal colonization. Their infants were categorized as GBS-exposed or GBS-unexposed groups. We comprehensively analyzed infant growth, gut microbiota, and metabolites during early life, along with maternal vaginal microbiota during pregnancy

SUBMITTER: Li S 

PROVIDER: S-EPMC11656753 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature