An alteration in the expression of cell wall structural proteins increases cell surface exposure of adhesins to promote virulence in <i>Candida glabrata</i>.

ABSTRACT: Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in immunocompromised individuals. Remodeling in cell wall components has been extensively exploited by fungal pathogens to adapt to host-derived stresses, as well as immune evasion. How this process contributes to C. glabrata pathogenicity is less understood. Here, we applied RNA sequencing and an in vivo invasive infection model to elucidate the prompt response of C. glabrata during infection. Fungal transcriptomes show a dramatic alteration in the expression of Srp1/Tip1-family cell wall structural proteins during systemic infection. Deletion of all six genes in this family (TIR2-5 and AWP6-7) that are upregulated

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11656777 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature