An hiPSC-CM approach for electrophysiological phenotyping of a patient-specific case of short-coupled TdP.

ABSTRACT:

Introduction

A healthy young woman, age 26 without prior cardiac complications, experienced an out-of-hospital cardiac arrest caused by ventricular fibrillation (VF), which coincided with a fever. Comprehensive diagnostics including echo, CMR, exercise testing, and genetic sequencing, did not identify any potential cause. This led to the diagnosis of idiopathic VF and installment of an implantable cardioverter defibrillator, which six months later appropriately intervened another VF episode under conditions comparable to the first event. A second diagnostic opinion concluded short-coupled Torsade de Pointes (scTdP), and the patient was started on a verapamil treatment.

Methods

From this patient, human induced pluripotent stem cell cardiomyocyte (hiPSC-CM) lines were generate

SUBMITTER: van Ham WB 

PROVIDER: S-EPMC11656816 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature