Production of Plant Virus-Derived Hybrid Nanoparticles Decorated with Different Nanobodies.

ABSTRACT: Viral nanoparticles (VNPs) are self-assembled nanometric complexes whose size and shape are similar to those of the virus from which they are derived. VNPs are arousing great attention due to potential biotechnological applications in fields like nanomedicine and nanotechnology because they allow the presentation of polypeptides of choice linked to the virus structural proteins. Starting from tobacco etch virus (TEV), a plant plus-strand RNA virus that belongs to the genus Potyvirus (family Potyviridae), here we describe the development of recombinant hybrid VNPs in Nicotiana benthamiana plants able of exposing simultaneously different proteins on their surface. This system is based on the synergic coinfection of TEV and potato virus X (PVX; Potexvirus), in whic

SUBMITTER: Lozano-Sanchez E 

PROVIDER: S-EPMC11656832 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature