Characterization of neuronal oscillations in the prelimbic cortex, nucleus accumbens and CA1 hippocampus during object retrieval task in rats predisposed to early life stress.

ABSTRACT:

Background

Early life stress (ELS) during the stress hypo-responsive period (SHRP) alters the curiosity-like behavior later during adolescence. Previous studies have shown maternal separation (MS) stress-induced heightened curiosity and associated risk-taking behavior in the object retrieval task (ORT). However, the neural correlates of curiosity in adolescent rats predisposed to early life stress remain unexplored. Hence, the present study aimed to investigate the neural oscillatory patterns and network characteristics in the regions implicated in curiosity behavior, such as the Prelimbic cortex (PL), Nucleus Accumbens (NAc), and CA1 of the Hippocampus. The local field potentials data were analysed to understand the neural activity patterns in these areas during the risky zone cro

SUBMITTER: Sharma SS 

PROVIDER: S-EPMC11656857 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature