Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) has numerous symptoms across organs and an unpredictable flare-remittance pattern. This has made it challenging to understand drivers of long-term SLE outcomes. Our objective was to identify whether changes in DNA methylation over time, in an actively flaring SLE cohort, were associated with remission and whether these changes meaningfully subtype SLE patients.

Methods

Fifty-nine multi-ethnic SLE patients had clinical visits and DNA methylation profiles at a flare and approximately 3 months later. Methylation was measured using the Illumina EPIC array. We identified sites where methylation change between visits was associated with remission at the follow-up visit using limma package and a time x remission interaction term. Models

SUBMITTER: Horton MK 

PROVIDER: S-EPMC11656870 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature