Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4).

ABSTRACT:

Background

Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The molecular basis for this impairment is largely unknown. Glucose uptake via glucose transporter GLUT4 is impaired in insulin resistance. In healthy muscle, acute injury stimulates glucose uptake. Whether decreased glucose uptake via GLUT4 impairs muscle regeneration is presently unknown. The goal of this study was to determine whether GLUT4 regulates muscle glucose uptake and/or regeneration following acute injury.

Methods

Tibialis anterior and extensor digitorum longus muscles from wild-type, control, or muscle-specific GLUT4 knockout (mG4KO) mice were injected with the myotoxin barium chloride to induce muscle injury. After 3, 5, 7, 10, 14, or 21

SUBMITTER: Sermersheim TJ 

PROVIDER: S-EPMC11656879 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature