Predicted breeding values for relative scrapie susceptibility for genotyped and ungenotyped sheep.

ABSTRACT:

Background

Scrapie is an infectious prion disease in sheep. Selective breeding for resistant genotypes of the prion protein gene (PRNP) is an effective way to prevent scrapie outbreaks. Genotyping all selection candidates in a population is expensive but existing pedigree records can help infer the probabilities of genotypes in relatives of genotyped animals.

Results

We used linear models to predict allele content for the various PRNP alleles found in Icelandic sheep and compiled the available estimates of relative scrapie susceptibility (RSS) associated with PRNP genotypes from the literature. Using the predicted allele content and the genotypic RSS we calculated estimated breeding values (EBV) for RSS. We tested the predictions on simulated data under different scenarios t

SUBMITTER: Eiriksson JH 

PROVIDER: S-EPMC11656908 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature