LL-37 regulates odontogenic differentiation of dental pulp stem cells in an inflammatory microenvironment.

ABSTRACT:

Background

Inflammation often causes irreversible damage to dental pulp tissue. Dental pulp stem cells (DPSCs), which have multidirectional differentiation ability, play critical roles in the repair and regeneration of pulp tissue. However, the presence of proinflammatory factors can affect DPSCs proliferation, differentiation, migration, and other functions. LL-37 is a natural cationic polypeptide that inhibits lipopolysaccharide (LPS) activity, enhances cytokine production, and promotes the migration of stem cells. However, the potential of LL-37 in regenerative endodontics remains unknown. This study aimed to investigate the regulatory role of LL-37 in promoting the migration and odontogenic differentiation of DPSCs within an inflammatory microenvironment. These findings establi

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11656940 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature