STING exerts antiviral innate immune response by activating pentose phosphate pathway.

ABSTRACT:

Background

The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator of interferon genes (STING) is a key component of this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored.

Methods

Metabolomics analysis was used for detecting metabolic alterations in spleens from STING knockout (KO) and wild-type (WT) mice. Co-immunoprecipitation was employed for determining ubiquitination of TKT. Mass spectrometry was used for detecting interaction proteins of STING. Enzyme activity kits were used for detecting the activities of TKT and G6PD.

Results

In this study, we demonstrate that herpes simplex virus (HSV) infection activates the pentose phosphate pathway (PPP) in hos

SUBMITTER: Wu DH 

PROVIDER: S-EPMC11656958 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature