Quantitative Comparisons of Progressive Supranuclear Palsy Rating Scale Versions Using Item Response Theory.

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is a neurodegenerative, late-onset disease that is challenging in terms of assessment. The Progressive Supranuclear Palsy Rating Scale (PSPRS), a 28-item clinician-reported scale, is the most established clinical outcome assessment method. Recently, the U.S. Food and Drug Administration (FDA) has proposed a subscale of 10 items as an alternative to full PSPRS.

Objectives

To quantitatively evaluate and compare the properties of full PSPRS and the FDA subscale using item response theory. To develop a progression model of the disease and assess relative merits of study designs and analysis options.

Methods

Data of 979 patients from four interventional trials and two registries were available for analysis. Our investigation

SUBMITTER: Gewily M 

PROVIDER: S-EPMC11657017 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature