Infantile colic is associated with development of later constipation and atopic disorders.

ABSTRACT:

Background

Infantile colic is a common condition with limited knowledge about later clinical manifestations. We evaluated the role of the early life gut microbiome in infantile colic and later development of atopic and gastrointestinal disorders.

Methods

Copenhagen Prospective Studies on Asthma in Childhood₂₀₁₀ cohort was followed with 6 years of extensive clinical phenotyping. The 1-month gut microbiome was analyzed by 16S rRNA sequencing. Infantile colic was evaluated at age 3 months by interviews. Clinical endpoints included constipation to age 3 years and prospectively diagnosed asthma and atopic dermatitis in the first 6 years of life, and allergic sensitization from skin prick tests, specific Immunoglobulin E, and component analyses.

Results

Of 695 ch

SUBMITTER: Stokholm J 

PROVIDER: S-EPMC11657018 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature