Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections.

ABSTRACT:

Background

Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of these environmental stressors can manifest through DNA methylation (DNAm). However, whether these epigenetic effects selectively target genes, pathways, and biological regulatory mechanisms remains unclear. Due to the frequency of human rhinovirus (HRV) infections throughout life (particularly in early development), we propose the use of HRV under controlled conditions can model the effect of multiple exposures to environmental stressors.

Methods

We generated a prediction model by combining transcriptome and DNAm datasets from human epithelial cells after repea

SUBMITTER: Risha MA 

PROVIDER: S-EPMC11657021 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature