Cognitive Impact of β-Amyloid Load in the Rapid Eye Movement Sleep Behavior Disorder-Lewy Body Disease Continuum.

ABSTRACT:

Background

Rapid eye movement sleep behavior disorder (RBD) is linked to the diffuse-malignant subtype and higher cognitive burden in Lewy body disease (LBD).

Objective

This study explores brain β-amyloid deposition and its association with cognitive decline across the RBD-LBD continuum.

Methods

Patients with isolated RBD (iRBD), Parkinson's disease with probable RBD (PDRBD), and dementia with Lewy bodies with probable RBD (DLBRBD) underwent ¹⁸F-florbetaben positron emission tomography, 3T magnetic resonance imaging scans, and comprehensive neuropsychological assessments. Subjects were categorized as cognitively normal (NC), mild cognitive impairment (MCI), or dementia. Global and regional standardized uptake value ratios (SUVR) were estimated in predefined

SUBMITTER: Woo KA 

PROVIDER: S-EPMC11657023 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature