Improved quality control of allergen products: Assessing the molecular allergen composition by mass spectrometry.

ABSTRACT:

Background

Natural allergen sources contain a variety of allergens, against which allergic subjects have developed individual sensitization profiles. Ideal allergen products for skin prick testing (SPT) and allergen immunotherapy (AIT) should contain the complete set of allergens of the respective allergen sources to cover all sensitization profiles. However, commercially available allergen products were shown to vary regarding their allergen composition.

Methods

The qualitative allergen composition of different SPT and AIT products produced from pollen of grasses, birch, mugwort and from house dust mites was assessed by a consistent high-resolution liquid chromatography-coupled tandem mass spectrometry method (LC-MS/MS).

Results

All major, mid-tier and most minor all

SUBMITTER: Augustin S 

PROVIDER: S-EPMC11657028 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature