Microneedles with Implantable Tip-Accumulated Therapeutics for the Long-Term Management of Psoriasis.

ABSTRACT: Methotrexate is successfully used as the gold standard for managing moderate-to-severe psoriasis. However, the low bioavailability and short half-life of the oral pills and the invasiveness of the parenteral injections make these suboptimal therapeutic options. Microneedles, bridging the advantages of the former forms, are successfully used to deliver methotrexate for different therapeutic purposes. However, the utilized dissolving microneedles demand frequent administration, potentially compromising patients' compliance. Additionally, the high toxicity of methotrexate prompts a quest for safer alternatives. Phloretin, a natural compound with confirmed antipsoriatic potential, emerges as a promising candidate. Herein, microneedle patches with separable, slow-degrading tips are developed fo

SUBMITTER: Moawad F 

PROVIDER: S-EPMC11657035 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature