Biomarkers for a less invasive strategy to predict children with eosinophilic esophagitis.

ABSTRACT:

Background

Noninvasive biomarkers for diagnosing and monitoring eosinophilic esophagitis (EoE) are currently lacking. This study evaluates 20 biomarkers in serum and saliva, aiming to assess their diagnostic potential in pediatric EoE patients and healthy individuals.

Methods

Blood and saliva from children undergoing upper endoscopy were analyzed for biomarkers, including absolute eosinophil count (AEC), eosinophil-derived neurotoxin (EDN), total and specific IgG₄-antibodies (sIgG₄), specific IgE-antibodies (sIgE) and 15-hydroxyeicosatetraenoic acid (15(S)-HETE). Some patients participated twice, forming a longitudinal cohort. The ability to use the biomarkers to predict the EoE diagnosis was evaluated.

Results

Analysis from 105 children divided

SUBMITTER: Thulin H 

PROVIDER: S-EPMC11657037 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature