Unilateral Magnetic Resonance-Guided Focused Ultrasound Lesion of the Subthalamic Nucleus in Parkinson's Disease: A Prospective Study.

ABSTRACT:

Background

Unilateral subthalamic nucleus (STN) ablation using magnetic resonance-guided focused ultrasound (MRgFUS) is being explored as a new treatment for asymmetric Parkinson's disease (PD).

Objectives

The aims were to study the efficacy and safety of this treatment in asymmetric PD patients and to characterize the lesions.

Methods

This prospective, single-center, open-label study evaluated asymmetric PD patients at 6 (n = 20) and 12 months (n = 12) after MRgFUS lesion of the STN. The primary outcome was the change in the Movement Disorders Society-Unified Parkinson's Disease Rating Scale, Part III (MDS-UPDRS III), score in off medication on the treated side and the adverse events (AEs) at 6-month follow-up. We also evaluated cognitive-neuropsychological changes,

SUBMITTER: Armengou-Garcia L 

PROVIDER: S-EPMC11657072 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature