Effects of childhood trauma on sustained attention in major depressive disorder: the mediating role of brain activity and functional connectivity.

ABSTRACT:

Background

Sustained attention deficits were reported more significant in patients with major depressive disorder (MDD) than in healthy controls (HCs), and are pivotal in both the development and aggravation of depression. Childhood trauma is also common in MDD and the exposure to childhood trauma may impede sustained attention and increase the treatment resistance in MDD. However, the underlying neuro-mechanisms link the childhood trauma to sustained attention deficits in MDD remain unclear.

Methods

We collected resting-state functional magnetic resonance imaging data, and measured childhood trauma severity using the Childhood Trauma Questionnaire and sustained attention using the Continuous Performance Test, Identical Pairs version. After excluding subjects with significan

SUBMITTER: Lai M 

PROVIDER: S-EPMC11657093 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature