Induction of tissue resident memory T cells by measles vaccine vector.

ABSTRACT: Measles live attenuated vaccine (MV) induces strong humoral and cellular systemic memory responses allowing the successful control of measles since decades. MV has also been adapted into a promising vaccine platform with several vaccine candidates in clinical development. To understand and document the tissue-scaled memory response induced by MV, we explored the specific induction and persistence of resident memory T cells (Trm) in the lungs and the liver, two critical targeted tissues for vaccine development against several diseases. Trm are a subset of non-circulating highly specialized T cells. They are found at multiple barrier and mucosal sites, conveniently positioned to rapidly react against pathogens. The induction of Trm in different tissues is therefore critical for vaccine devel

SUBMITTER: Vera-Peralta H 

PROVIDER: S-EPMC11657113 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature