Physiological measures variability and risks of heart disease and stroke: evidence from three cohort studies.

ABSTRACT:

Background

The overall effect of long-term variability in physiological measures on cardiovascular health of older adults and the underlying mechanic pathway remain uncertain.

Methods

We constructed a composite score (0 ~ 3) of variability in physiological measures, including blood pressure, pulse rate, and body mass index, in older adults from the China Health and Retirement Longitudinal Study (CHARLS) 2011 ~ 2015, the Health and Retirement Study (HRS) 2006/2008 ~ 2014/2016, and the UK Biobank 2006 ~ 2019. The associations of the composite score with incident risks of heart disease and stroke were assessed. The mediation roles of several biomarkers were explored.

Results

A higher composite score was related to increased incident risk of heart disease in older adults

SUBMITTER: Liu W 

PROVIDER: S-EPMC11657114 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature