Immunomodulatory features of MSC-derived exosomes decorated with DC-specific aptamer for improving sublingual immunotherapy in allergic mouse model.

ABSTRACT:

Introduction

Sublingual immunotherapy (SLIT) is an effective and injection-free route for allergen-specific immunotherapy (AIT). Mesenchymal stromal/stem cell (MSC)-derived exosomes (Exo) has been identified as a novel delivery platform with immunomodulatory capacities. In addition, targeting agents such as aptamers (Apt) have been extensively used for specific delivery approaches such as direct delivery of allergen formulations to dendritic cells (DC) to improve the efficacy of specific immunotherapy. In this study, we assessed the effects of MSC-derived Exos containing ovalbumin (Ova) which decorated with DC-specific aptamer in allergic rhinitis mice model.

Materials and methods

Exos were harvested from adipose tissue-derived MSCs, and Exo-Apt-Ova complex was formulated. T

SUBMITTER: Sadeghi M 

PROVIDER: S-EPMC11657170 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature