CD69⁺CD103⁺CD8⁺ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate of patient mortality. CD8⁺ tissue-resident memory T (TRM) cells are strategically positioned to mediate effective anti-tumor responses. However, the characteristic surface molecules and functions of CD8⁺ TRM cells exhibit significant heterogeneity.

Methods

The roles and anti-tumor biological functions of different CD8⁺ TRM subsets in CRC were determined by clinical CRC samples, bioinformatics analysis, and in vitro experiments including co-culture experiments and transwell migration assays. The signaling pathways that synergistically regulate the differentiation of CD8⁺ TR

SUBMITTER: Wu ZX 

PROVIDER: S-EPMC11657194 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature