Charting the global footprint of borderline oxacillin-resistant <i>Staphylococcus aureus</i> (BORSA): the first systematic review and meta-analysis.

ABSTRACT: Borderline oxacillin-resistant Staphylococcus aureus (BORSA) has been a persistent yet under-researched concern in the realm of antibiotic resistance, characterized by unique resistance mechanisms and potential for severe infections. This systematic review and meta-analysis consolidates data from 29 studies encompassing 18,781 samples, revealing a global BORSA prevalence of 6.6% (95% CI [4.0-10.7]). The highest prevalence was found in animals (46.3%), followed by food (8.9%), and humans (5.1%). Notably, significant regional disparities were observed, with Brazil exhibiting the highest prevalence at 70.0%, while The Netherlands reported just 0.5%. These findings underscore the multifaceted nature of BORSA epidemiology, influenced by local antibiotic usage practices and healthcare inf

SUBMITTER: Engku Abd Rahman ENS 

PROVIDER: S-EPMC11657201 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature