Double gas transfer factors (DLCO-DLNO) at rest in patients with congenital heart diseases correlates with their ventilatory response during maximal exercise.

ABSTRACT:

Aim

Exercise capacity is altered in congenital heart diseases (CHD) with potentially impaired pulmonary perfusion adaptation during exercise, such as in single ventricle or in significant pulmonary regurgitation. This study aimed to evaluate the value of double gas transfer factor analysis, at rest in conjunction with postural manoeuvres, to explore the various components of pulmonary gas transfer and its association with exercise capacity.

Methods

A total of 40 subjects (24 CHD, 16 controls) underwent a combined measurement of lung diffusing capacity for carbon monoxide and nitric oxide (DLCO-DLNO) to determine pulmonary membrane diffusion (Dm) and Vcap, in sitting then supine position. CHD patients performed a maximal cardiopulmonary exercise test.

Results

Compared

SUBMITTER: De La Villeon G 

PROVIDER: S-EPMC11657256 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature