Sex differences in mitochondrial gene expression during viral myocarditis.

ABSTRACT:

Background

Myocarditis is an inflammation of the heart muscle most often caused by viral infections. Sex differences in the immune response during myocarditis have been well described but upstream mechanisms in the heart that might influence sex differences in disease are not completely understood.

Methods

Male and female BALB/c wild type mice received an intraperitoneal injection of heart-passaged coxsackievirus B3 (CVB3) or vehicle control. Bulk-tissue RNA-sequencing was conducted to better understand sex differences in CVB3 myocarditis. We performed enrichment analysis and functional validation to understand sex differences in the transcriptional landscape of myocarditis and identify factors that might drive sex differences in myocarditis.

Results

As expected, the

SUBMITTER: Di Florio DN 

PROVIDER: S-EPMC11657264 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature