New prognostic index for neoadjuvant chemotherapy outcome in patients with advanced high-grade serous ovarian cancer.

ABSTRACT:

Background

A validated prognostic index for the outcome of patients with advanced high-grade serous ovarian cancer (HGSOC) undergoing neoadjuvant chemotherapy (NACT) remains elusive. To address this need, we developed an ovarian neoadjuvant chemotherapy prognostic index (ONCPI) to improve predictive accuracy.

Methods

We encompassed an analysis of the clinicopathological characteristics of patients with advanced HGSOC who were administered platinum-based NACT. Blood inflammatory composite markers were calculated and converted into binary values using optimal cutoffs. Omental hematoxylin and eosin (H&E) stained slides were selected for the assessment of chemotherapy response score (CRS), which served as a measure of NACT efficacy. Logistic regression analysis and Cox proportio

SUBMITTER: Huo C 

PROVIDER: S-EPMC11657423 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature