Remote ischaemic conditioning for neurological disorders-a systematic review and narrative synthesis.

ABSTRACT:

Introduction

Remote ischaemic conditioning (RIC) refers to the use of controlled transient ischemic and reperfusion cycles, commonly of the upper or lower limb, to mitigate cellular damage from ischaemic injury. Preclinical studies demonstrate that RIC may have a neuroprotective effect and therefore could represent a novel therapeutic option in the management of neurological disorders. The aim of this review is to comprehensively describe the current clinical evidence of RIC in neurological disorders.

Methods

A computerised search of EMBASE and OVID MEDLINE was conducted from 2002 to October 2023 for randomised controlled trials (RCTs) investigating RIC in neurological diseases.

Results

A total of 46 different RCTs in 12 different neurological disorders (n = 7544) wer

SUBMITTER: Alhashimi A 

PROVIDER: S-EPMC11657452 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature