Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide.

ABSTRACT: The prospective use of food additive titanium dioxide (E171 TiO₂) in a variety of fields (food, pharmaceutics, and cosmetics) prompts proper cellular cytotoxicity and transcriptomic assessment. Interestingly, smaller-sized E171 TiO₂ can translocate in bloodstream and induce a diverse immunological response by activating the immune system, which can be either pro-inflammatory or immune-suppressive. Nevertheless, their cellular or immunologic responses in a heterogeneous population of the immune system following exposure of food additive E171 TiO₂ is yet to be elucidated. For this purpose, we have used male Sprague-Dawley rats to deliver E171 TiO₂ (5 mg/kg bw per day) via non-invasive intratracheal instillation for 13 weeks. After the 4 weeks recov

SUBMITTER: Perumalsamy H 

PROVIDER: S-EPMC11657454 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature