Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint.

ABSTRACT:

Background

Cancer radiotherapy (RT) still has limited clinical success because of the obstacles including radioresistance of hypoxic tumors, high-dose X-ray-induced damage to adjacent healthy tissue, and DNA-damage repair by intracellular PD-L1 in tumor.

Results

Therefore, to overcome these obstacles multifunctional core-shell BMS@Pt₂Au₄ nanoparticles (NPs) are prepared using nanoprecipitation followed by electrostatic assembly. Pt₂Au₄ clusters are released from BMS@Pt₂Au₄ NPs to alleviate tumor hypoxia by catalyzing the decomposition of endogenous H₂O₂ to generate O₂ as well as by enhancing X-ray deposition at the tumor site, which thereby reduce the required X-ray dose. The r

SUBMITTER: Ding G 

PROVIDER: S-EPMC11657501 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature