Identification of pyroptosis-associated miRNAs in the immunoscape and prognosis of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma is one of the most prevalent types of liver malignancy and poses a severe threat to global health. Despite recent improvements in therapeutic approaches, treatment options for patients with advanced or recurrent HCC are still limited.

Materials and methods

Our study analyzed miRNA differential expression using data from hepatocellular carcinoma patients in the Cancer Genome Atlas. Pyroptosis-related genes were identified from gene cards. Differential expression of miRNAs was analyzed using DESeq2 and visualized using ggplot2 and pheatmap. A prognostic risk model for pyroptosis-associated miRNAs was constructed using LASSO regression and validated by principal component analysis, Kaplan-Meier survival and ROC curve analysis. We also perform

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11657507 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature