Bile acids in follicular fluid: potential new therapeutic targets and predictive markers for women with diminished ovarian reserve.

ABSTRACT:

Objective

To investigate the changes in bile acid (BA) metabolites within the follicular fluid (FF) of patients with diminished ovarian reserve (DOR) and to identify novel diagnostic markers that could facilitate early detection and intervention in DOR patients.

Design

A total of 182 patients undergoing assisted reproductive technology (ART) were enrolled and categorized into the normal ovarian reserve (NOR) group (n = 91) or the DOR group (n = 91) to measure BA levels in FF. To identify the changes in granulosa cells (GCs), we collected GCs from an additional 7 groups of patients for transcriptome sequencing.

Setting

Reproductive medicine center within a hospital and university research laboratory.

Population

A total of 182 patients undergoing assisted reprodu

SUBMITTER: Ding S 

PROVIDER: S-EPMC11657518 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature