Difference in fecal and oral microbiota between pancreatic cancer and benign/low-grade malignant tumor patients.

ABSTRACT:

Background

Significant gaps exist in understanding the gastrointestinal microbiota in patients with pancreatic cancer (PCA) versus benign or low-grade malignant pancreatic tumors (NPCA). This study aimed to analyze these microbiota characteristics and explore their potential use in distinguishing malignant pancreatic lesions.

Methods

Between September 2020 and May 2024, fecal and oral samples were collected from 121 patients undergoing surgical resection or diagnostic biopsy of pancreatic lesions, including 75 patients with PCA and 46 patients with NPCA, and 16s rRNA sequencing was performed. Random forest models based using fecal and oral microbiota data were developed to diagnose PCA and NPCA, with performance assessed using the leave-one-out cross validation method.

Re

SUBMITTER: Li P 

PROVIDER: S-EPMC11657520 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature