Streptococcus suis infection on European farms is associated with an altered tonsil microbiome and resistome.

ABSTRACT: Streptococcus suis is a Gram-positive opportunistic pathogen causing systemic disease in piglets around weaning age. The factors predisposing to disease are not known. We hypothesized that the tonsillar microbiota might influence disease risk via colonization resistance and/or co-infections. We conducted a cross-sectional case-control study within outbreak farms complemented by selective longitudinal sampling and comparison with control farms without disease occurrence. We found a small but significant difference in tonsil microbiota composition between case and control piglets (n=45+45). Variants of putative commensal taxa, including Rothia nasimurium, were reduced in abundance in case piglets compared to asymptomatic controls. Case piglets had higher relative abundan

SUBMITTER: Fredriksen S 

PROVIDER: S-EPMC11657566 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature