Effects of psychedelics on neurogenesis and broader neuroplasticity: a systematic review.

ABSTRACT: In the mammalian brain, new neurons continue to be generated throughout life in a process known as adult neurogenesis. The role of adult-generated neurons has been broadly studied across laboratories, and mounting evidence suggests a strong link to the HPA axis and concomitant dysregulations in patients diagnosed with mood disorders. Psychedelic compounds, such as phenethylamines, tryptamines, cannabinoids, and a variety of ever-growing chemical categories, have emerged as therapeutic options for neuropsychiatric disorders, while numerous reports link their effects to increased adult neurogenesis. In this systematic review, we examine studies assessing neurogenesis or other neurogenesis-associated brain plasticity after psychedelic interventions and aim to provide a comprehensive picture o

SUBMITTER: Lima da Cruz RV 

PROVIDER: S-EPMC11657683 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature