CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. However, the precise mechanisms by which CD2AP is linked to AD pathogenesis remain unclear.

Methods

The spatiotemporal expression pattern of CD2AP was determined. Then, we generated and characterized an APP/PS1 mouse model with neuron-specific Cd2ap deletion, using immunoblotting, immunofluorescence, enzyme-linked immunosorbent assay, electrophysiology and behavioral tests. Additionally, we established a stable CD2AP-knockdown SH-SY5Y cell line to furth

SUBMITTER: Xue YY 

PROVIDER: S-EPMC11657702 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature