What can we learn from systematic segmental analysis of fetal heart by postmortem micro-CT: Is it time to change approach?

ABSTRACT:

Background

Postmortem analysis of fetal heart is crucial but challenging. Alternative techniques to autopsy have been studied. We investigate micro-CT diagnostic accuracy in the analysis of fetal heart coming from early and late termination of pregnancy.

Methods

Micro-CT and autopsy analyzed human fetal heart using twenty-six indices of cardiac anatomy derived from segmental approach. Sub-analysis of smaller specimens was performed. Primary outcome is the agreement between techniques. Secondary outcomes are sensitivity, specificity, positive and negative predictive value. Indices are defined "visible" or "non-visible" (primary end point) and "normal", "abnormal" or "non-diagnostic" (secondary end point).

Results

Fifty-five cases were included. Agreement was 74.5% and

SUBMITTER: Sandrini C 

PROVIDER: S-EPMC11657735 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature