Drug susceptibility testing of Nocardia spp. using the disk diffusion method.

ABSTRACT:

Background

Drug susceptibility testing (DST) for Nocardia spp. is essential to initiate effective antibiotic therapy. Currently, the only recommended technique is the determination of minimum inhibitory concentrations (MICs) by microdilution. This method can be tedious to perform, despite the availability of ready-to-use plates. Herein, the aim was to determine the critical inhibition diameters specific to Nocardia spp.

Methods

MICs of 134 Nocardia isolates were determined by microdilution. Interpretative categories (Susceptible/Intermediate/Resistant) were determined using Clinical and Laboratory Standards Institute breakpoints. In parallel, disk diffusion DST was performed. Receiver-operating-characteristic (ROC) curves were constructed to determine the inhibition diameter

SUBMITTER: Prudhomme C 

PROVIDER: S-EPMC11657736 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature