Distribution of spine classes shows intra-neuronal dendritic heterogeneity in mouse cortex.

ABSTRACT:

Significance

Neuronal dendritic spines are central elements for memory and learning. Their morphology correlates with synaptic strength and is a proxy for function. Classic light microscopy cannot resolve spine morphology well, and techniques with higher resolution (electron microscopy and super-resolution light microscopy) typically do not provide spine data in large fields of view, e.g., along entire dendrites. Therefore, it remains unclear if spine types are organized on mesoscopic scales, despite their undisputed importance for understanding the brain.

Aim

Recently, it was shown that the distribution of spine type is dendrite-specific in the turtle cortex, suggesting a mesoscopic organization, but leaving the question open if such a dendrite specificity also exists in ma

SUBMITTER: Theobald CC 

PROVIDER: S-EPMC11657875 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature