Peripheral immune cell dysregulation following diffuse traumatic brain injury in pigs.

ABSTRACT: Traumatic brain injury (TBI) is a global health problem affecting millions of individuals annually, potentially resulting in persistent neuropathology, chronic neurological deficits, and death. However, TBI not only affects neural tissue, but also affects the peripheral immune system's homeostasis and physiology. TBI disrupts the balanced signaling between the brain and the peripheral organs, resulting in immunodysregulation and increasing infection susceptibility. Indeed, secondary infections following TBI worsen neurological outcomes and are a major source of mortality and morbidity. Despite the compelling link between the damaged brain and peripheral immune functionality, little is known about how injury severity affects the peripheral immune system in closed-head diffuse TBI, the most

SUBMITTER: Wofford KL 

PROVIDER: S-EPMC11657926 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature