Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa.

ABSTRACT:

Background

Gaining a comprehensive understanding of the genetic mechanisms underlying insecticide resistance in malaria vectors is crucial for optimising the effectiveness of insecticide-based vector control methods and developing diagnostic tools for resistance management. Considering the heterogeneity of metabolic resistance in major malaria vectors, the implementation of tailored resistance management strategies is essential for successful vector control. Here, we provide evidence demonstrating that two highly selected mutations in CYP6P4a and CYP6P4b are driving pyrethroid insecticide resistance in the major malaria vector Anopheles funestus, in West Africa.

Results

Continent-wide polymorphism survey revealed escalated signatures of directional selection of both genes be

SUBMITTER: Tatchou-Nebangwa NMT 

PROVIDER: S-EPMC11657943 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature